Changes in leukocyte population after ozonated
autohemoadministration in cows with inflammatory diseases.
Department of Large Animal Internal Medicine,
School of Veterinary Medicine and Animal Sciences, Kitasato University,
Towada, Aomori 034-8628, Japan.
In this study, we investigated whether ozonated
autohemoadministration (OAHA) influences leukocyte populations in cows
with clinical inflammatory disease. Eleven cows with inflammatory
disease (Inflammatory Group) and three healthy cows (Control Group) were
used for this study. The CD4(+)/CD8(+) ratio in the Inflammatory Group
increased significantly compared to that in the Control Group 3 to 4
days after OAHA treatment. In the Inflammatory Group, the number of
CD14(+) cells decreased gradually after OAHA, but CD14(+) levels
remained stable in the Control Group. The number of MHC class-II(+)
cells decreased gradually in the Inflammatory Group, but increased
gradually in the Control Group, and the difference between the groups
was significant on day 14 after OAHA. These findings suggest a possible
difference in the activation of immune response after OAHA in infected
cows compared to healthy cows.
PMID: 16520542 [PubMed - indexed for MEDLINE]