The level of some acute phase proteins, total protein,
gamma-globulins and activity of lysozyme in blood plasma of rats
supplemented with vitamin E and exposed to ozone.
Department of Pathology and Pharmacology, Faculty
of Veterinary Medicine, University of Warmia and Mazury in Olsztyn,
Oczapowskiego 13, 10-719 Olsztyn, Poland. email@example.com
In rats exposed for 28 days (5 hours a day) to ozone
at a concentration of 0.5 ppm and receiving alpha-tocopherol at doses of
4.5 mg/rat and 15 mg/rat, levels of acute phase proteins
(APP)--C-reactive protein (CRP), ceruloplasmin (Cp), total protein,
gamma-globulins, and activity of lysozyme in blood serum were studied.
The assays were performed in the presence of respective control groups,
i.e. rats receiving the same doses of alpha-tocopherol but not exposed
to ozone, a group of animals not supplemented with vitamin but exposed
to ozone, a group of animals injected with physiological fluid and a
control group not subjected to any of the treatments. The study revealed
that the ozone-exposed animals had an increased lysozyme activity and a
decreased total protein level. However, in rats protected by
alpha-tocopherol and exposed to ozone, the concentration of APP,
lysozyme activity and total protein were found to be decreased. Similar
relationships also occurred in animals receiving alpha-tocopherol and
not exposed to ozone.
PMID: 15633788 [PubMed - indexed for MEDLINE]