Ozone Information For Clinicians

Research References

© Dr Julian Holmes
2015


Ozone Information

General Review Reading
General Surface & Air Sterilisation
Integrating Ozone Treatment - Bad Breath
Integrating Ozone Treatment – Oral Hygiene
Head & Neck Inflammation
Dental Water Lines
Financial Implications of Ozone Treatment in Dental Care
Water Sterilisation
Bio-Chemistry / Toxicology of Ozone & Ozonoids
General Medicine
Treatment of Infections - Bacterial
Treatment of Infections - Fungal
Treatment of Infections - Viral
Treating Skin Infections and Diseases
Treating Ear Infections with Ozone
Infections of the Throat
Internal Use of Ozonoids - Upper Gut
Internal Use of Ozonoids - Lower Gut
Internal Use of Ozonoids - Vaginal
Treatment of Infections - Bone Infections
Internal Use of Ozone & Ozonoids – Lung Disease
Internal Use of Ozone & Ozonoids - Cancer
Topical Use of Ozone & Ozonoids - Cancer
Book Index.


General Review Reading

Maslennikov O, Budilin S, Filatov D. Ozone Therapy in Clinical Practice.
Rogers G. Ozone and The Politics of Medicine.

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General Surface & Air Sterilisation

Kleinmann H. OZONE - for Powerful Sterilization. In "Personal Notes", MD, German Research Authority.
Rideal EK. OZONE - Indispensable in Schools. Report to National Warm Air, Heating and Ventilating Association".

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Ozone in Dental Practice – General Discussion Papers

IADR Abstracts; 0165 Ozone in Dentistry E.F. REICH, Biberach, Germany. Ozone is a very powerful oxidizer, which is used for disinfection in the food industry, medicine and water treatment. For a few years it is used in dentistry to treat caries in a more causal way than with the use of operative procedures. Besides ...
Holmes J. Ozone – an Overview; Part 1 & Part 2. Published 2005
Holmes J. A New Dental Practice. Awaiting Publication, January 2007.
Holmes J. Changes in Dental Care. Awaiting Publication, January 2007.
Holmes J. The FDA & Ozone Treatment in the USA. Awaiting Publication, January 2007.

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Anxiety & Fear of Dental Treatment – Effect of Ozone Technologies

Dahnhardt JE, Jaeggi T, Scheidegger N, Kellerhoff N, Francescut P, Lussi A. Treating Caries in Anxious Children with Ozone: Parents' Attitudes after the First Session. IADR Abstract 2003
Dahnhardt JE, Jaeggi T, Scheidegger N, Kellerhoff N, Francescut P, Lussi A. Treating caries in anxious children with ozone: parents’ attitudes after the first session. J Dent Res 2003; 82:B-265.
Domingo H, Abu-Naba’a L, Al Shorman H, Holmes J, Freeman R, Lynch L. Reducing Barriers to Care in Patients Managed with Ozone. IADR Abstract 3473; 2004.
Domingo H, Abu-Naba'a L, Al Shorman H, Holmes J, Marshdeh MM, Abu-Salem AT, Freeman R, Lynch E. Reducing Barriers to Care in Patients Managed with Ozone. IADR Abstract 2004.
Domingo H, Abu-Naba’a L, Al Shorman H, Holmes J, Marashdeh MM, Abu-Salem OT, Smith C, Freeman R, Lynch E. Reducing Barriers to Care in Patients Managed with Ozone. AADR Abstract 677; 2003.
Freeman R, Holmes J, Lynch E. Ozone: A New Treatment Modality For Dentally Anxious Patients. Quintessence, in “Ozone; The Revolution In Dentistry”, 2002.
IADR Abstracts; Patients Attitudes to Caries Management using Ozone L. STEIER 1, G. STEIER 2, R. FREEMAN 3, H. DOMINGO 3, and E. LYNCH 4, 1 Private Practice, Mayen, Germany, 2 Tufts University, Medford, MA, USA, 3 Queen's University of Belfast, United Kingdom, 4 Queens University Belfast, England. Ozone is currently ...
IADR Abstracts; 2034 Treating Caries in Anxious Children with Ozone: Parents' Attitudes after the First Session J.E. DÄHNHARDT, T. JAEGGI, N. SCHEIDEGGER, N. KELLERHOFF, P. FRANCESCUT, and A. LUSSI, University of Bern, Switzerland. Treating anxious children remains a challenge in pediatric dentistry. Many times the ...
IADR Abstracts; Attitudes of Patients to Ozone in a General Practice D. JOSHI, Private practice, London, United Kingdom. Ozone has been shown to clinically reverse carious lesions. Objectives: This study aimed to assess the attitudes of patients to a new treatment method of treating caries with an ozone delivery system ...
IADR Abstracts; 2069 Patients' Attitudes toward and Satisfaction with Managing Caries with Ozone as a Routine Treatment in Dental Private Practice G.D. MEGIGHIAN, and M.V. DAL VERA, Private Practice, Verona, Italy. Ozone with the HealOzone (KaVo, Germany) is currently being used as an alternative treatment of dental ...

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Caries Initiation & Bio-Molecule Papers

Claxson AWD, Smith C, Turner MD, et al. Oxidative modification of salivary biomolecules with therapeutic levels of ozone. J Dent Res 2002; 81:A-502.
Grootveld M, Holmes J, Johnson N, Silwood C, Baysan A, Lynch E. Oxidative Consumption of Root Caries Biomolecules by Ozone. Queen's University of Belfast, United Kingdom IADR Abstract 2003.
Lynch E, Silwood C, Abu-Naba’a L, Al Shorman H, Baysan A, Holmes J, Grootveld M. Oxidative Consumption of Root Caries Biomolecules using Ozone. J Caries Res 38:364; 2004.
Lynch E, Silwood C, Smith C, Grootveld M. Oxidising actions of an antibacterial ozone-generating device towards root caries biomolecules. J Dent Res 2002; 81:A-138.
Smith C, Lynch F, Baysan A, et al. Oxidative consumption of root caries biomolecules by a novel antibacterial ozone delivery system. J Dent Res 2001; 80:1178.
IADR Abstracts; Ozone Effects on in vitro Biofilm E. ZAURA, Academic Centre for Dentistry Amsterdam, Netherlands, and J.M. TEN CATE, Academic Centre for Dentistry Amsterdam (ACTA), Netherlands. Ozone is a very powerful oxidizer that oxidizes any organic matter on its way. This property makes ozone a potent disinfectant ...
IADR Abstracts; The Use of Ozone in Dentistry - Antimicrobial and Cellular Aspects K.C. HUTH 1, K. KAMERECK 2, K. BRAND 2, and R. HICKEL 1, 1 University of Munich, Germany, 2 Technische Universität München, Munich, Germany. Recently, the use of ozone as an antiseptic agent has become a relevant topic in dentistry. ...
IADR Abstracts; Ability of Therapeutic Levels of Ozone to Oxidatively Consume Biomolecules C. SMITH, M. GROOTVELD, C. SILWOOD, L. ABU-NABA'A, H. AL SHORMAN, and E. LYNCH, Queen's University of Belfast, United Kingdom Objectives: The powerful microbiocidal activity of ozone (O3)is well known and previous investigations ...
IADR Abstracts; 2114 Oxidative Consumption of Biomolecules by Therapeutic Levels of Ozone M. TURNER, M. GROOTVELD, C. SILWOOD, and E. LYNCH, Queens University, Belfast, United Kingdom. Objectives: The potent microbiocidal actions of ozone (O3) are well known and recent investigations have demonstrated its potential ...

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Assessing Treatment Needs and Diagnosis

IADR Abstracts; 0683 Ozone Treatment of Occlusal Caries in Primary Teeth: Immediate Effects and Correlation of Diagnostic Methods M. MARASHDEH, O. ABU-SALEM, and E. LYNCH, Queen's University, Belfast, United Kingdom. Ozone (O3) has been clinically proven to reverse fissure caries and root caries. It is now being further ...
IADR Abstracts; 3469 Immediate Effect of Ozone Application In-vivo on DIAGNOdent Readings L. ABU-NABA'A, Jordan University of Science and Technology, Irbid, Jordan, H.M. AL SHORMAN, Queen's University of Belfast, United Kingdom, and E. LYNCH, Queens University Belfast, United Kingdom. Ozone is proposed as a novel pharmaceutical ...
IADR Abstracts; 2756 In vivo Treatment of Occlusal Caries with Ozone: One and Two Months' Effect with Light-induced Fluorescence (QLF) as Diagnostic Methods G.D. MEGIGHIAN, and L. BERTOLINI, Private Practice, Verona, Italy. Ozone has been proven to reverse root caries and pit and fissure carious lesions clinically ...

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Dental Microbiology and Sensitivity to Ozone

Nagayoshi M, Fukuizumi T, Kitamura C, et al. Efficacy of ozone on survival and permeability of oral microorganisms. Oral Microbiol Immunol 2004; 19:240–246.
Ozone: The Revolution in Dentistry. Copenhagen: Quintessence Publishing, 2004:155–164, ISBN 18-5097-08-82.
Schwan L, Bamfaste M. Experiences with the use of chlorine gas and ozone in the treatment of root gangrene and dental granuloma. Dtsch Zahnarztl Z. 1951 Mar 1;6(5):248-63.
Shargawi JM, Theaker ED, Drucker DB, et al. Sensitivity of Candida albicans to negative air ion streams. J Appl Microbiol 1999; 87:889–897.
IADR Abstracts; The Use of Ozone in Dentistry - Antimicrobial and Cellular Aspects K.C. HUTH 1, K. KAMERECK 2, K. BRAND 2, and R. HICKEL 1, 1 University of Munich, Germany, 2 Technische Universität München, Munich, Germany. Recently, the use of ozone as an antiseptic agent has become a relevant topic in dentistry. ...

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Diseases of the Mouth - Dental Infections

Brauner A. Clinical studies of therapeutic results from ozonized water for gingivitis and periodontitis. Zahnarztl Prax 1991; 42:48–50.
Chahverdiani B, Thadj-Bakhche A. Ozone treatment in root canal therapy. Introduction and general discussion. Acta Med Iran. 1976;19(3):192-200.
Chang H, Fulton C, Lynch E. Antimicrobial Efficacy of Ozone on Enterococcus faecalis. IADR Abstract 2003
Claxson AWD, Smith C, Turner MD, et al. Oxidative modification of salivary biomolecules with therapeutic levels of ozone. J Dent Res 2002; 81:A-502.
Cruz C, Menéndez S, Martínez ME, Clavera T. Application of Ozonised Oil in the Treatment of Alveolitis.
Durnovo F, Kinyapina I, Kontorschikova C. Ozone Influence on Pro-Inflammatory Process in Maxillo-Facial Part of Head and Neck.
Ebensberger U, Pohl Y, Filippi A. PCNA-expression of cementoblasts and fibroblasts on the root surface after extraoral rinsing for decontamination. Dent Traumatol 2002; 18:262–266.
Holmes J. Management of Volatile Sulphur Compounds with Ozone. ISBOR 2003
Holmes J. The use of Ozonated Water as a Mouth Rinse to Reduce Bad Breath. IADR, 2003

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Integrating Ozone Treatment - Bad Breath

Holmes J. Management of Volatile Sulphur Compounds with Ozone. ISBOR 2003.
Holmes J. The use of Ozonated Water as a Mouth Rinse to Reduce Bad Breath. IADR, 2003

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Integrating Ozone Treatment – Oral Hygiene

Legrá G, Turrent J, Menéndez S, Luis M. Experiences with Ozone Therapy in the Sutton Disease (Peridentitis Mucous Necrotica Recurrens). A Case Report.
Lemus L, Ordaz E. Application of Oleozon in the Treatment of Subprosthesis Stomatitis.
Lemus L, Ordaz E, Rodríguez E. Application of Oleozon in the Treatment of Subprosthesis Stomatitis.
Lukinikh LM, Kosjuga SY. The use of Ozone for the Intensification and Optimization of Oral Hygiene.
Sorokina S, Lukinych L. Ozone Therapy as a Part of a Complex Treatment of a Paradontium Disease.
Sorokina S, Zaslavskaja M. A Comparative Study of a Bactericidal Activity of Ozonized Solutions during Treatment of Inflammatory Diseases of Paradontium.

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Effect of Ozone on Dental Materials

IADR Abstracts; 2008 Effect of Ozone on Surface Hardness of Restorative Materials D. CAMPBELL 1, D.L. HUSSEY 2, L. CUNNINGHAM 2, and E. LYNCH 2, 1 Royal Group of Hospitals, Belfast, United Kingdom, 2 Queen's University, Belfast, United Kingdom. Objective: There has been much recent interest in the use of ozone as an ...
IADR Abstracts; 1362 Ozone and Sealant Treatment of Root Caries L. STEIER, Private Practice, Mayen, Germany, and G. STEIER, Tufts University, Medford, MA, USA Arrested root caries may need the use of flowable composite resins to improve esthetics. Objectives: To assess the efficacy of ozone (HealOzone, KaVo) to reverse ...
IADR Abstracts; 0062 Influence of ozone treatment on marginal adaptation of fissure sealing K.-A. HILLER, M. FEDERLIN, A. MACKOW, M. REDLICH, and G. SCHMALZ, University of Regensburg, Germany. Objectives: In the present study the influence of supplementary ozone treatment prior to fissure sealing upon the adhesion ...
IADR Abstracts; 0063 Bond strength of glass-ionomers to dentine after Ozone treatment B. CZARNECKA 1, P. DERÊGOWSKA-NOSOWICZ 1, M. PRYLINSKI 2, and H. LIMANOWSKA-SHAW 1, 1 University of Medical Sciences,Poznañ, Poland, Poland, 2 School of Dental Technicians and Hygienist, Poznañ, Poland. Bond strength of ...
IADR Abstracts; 0843 15-months Sealant Retention Over Ozone-treated Occlusal Caries L. STEIER, Private Practice, Mayen, Germany, E. LYNCH, Queens University Belfast, England, and G. STEIER, Tufts University, Medford, MA, USA. Ozone is recommended combined with a “bonded” flowable composite resin sealant (FCS) as a ...

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Restoration of Ozone Treated Lesions

IADR Abstracts; Restoration of Ozone treated carious lesions L. STEIER, Dental Clinic, Mayen, Germany. Some Dentists are currently treating stained carious lesions with Ozone without placing any restoration whilst others are bonding composite resin on top of the Ozone treated stained lesion. Objectives: The aim of ...
IADR Abstracts; Ozone and Sealant Treatment of Root Caries after 6-Months L. STEIER, Private Practice, Mayen, Germany, G. STEIER, Tufts University, Medford, MA, USA, H. DOMINGO, Queen's University of Belfast, England, and E. LYNCH, Queens University Belfast, United Kingdom. Arrested root caries may need the use of ...

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Head & Neck Inflammation

Durnovo F, Kinyapina I, Kontorschikova C. Ozone Influence on Pro-Inflammatory Process in Maxillo-Facial Part of Head and Neck.

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Dental Water Lines

Holmes J. Dental Unit Water Lines (DUWL’s) – A Review of The Problem & Solutions. Awaiting Publication, 2007.
IADR Abstracts; Control of planktonic and biofilm contamination in a laboratory dental unit water system. ... were assessed for biofilm removal. Ten products, Combizyme (1.25%) Tegodor (1%), Spor-Klenz (Neat), Dialox (Neat), Tegodor (1%), Bleach (0.5%), Ozone (200mg/hour), Chlorhexidine (0.2%), Ultrakleen (powder) and Betadene (10%) were tested overnight (16h). Results: Flushing did not reduce the viability ...
IADR Abstracts; Rapid Detection of Microbial-Derived Components in Dental Unit Water Lines by NMR Analysis. ... included the amino acids alanine and glycine, and also a series of aromatic compounds. Treatment of DUWL’s with the powerful microbiocidal agent ozone gave rise to a substantial reduction in many of the MFPs detectable in samples collected 18 hr. after treatment (p < 0.01). Conclusions: High field ...
IADR Abstracts; 0711 Ozone, An Effective Treatment For Dental Unit Water Lines H.M. AL SHORMAN, L. ABU-NABA'A, W.A. COULTER, and E. LYNCH, Queens University Belfast, United Kingdom. Ozone (O 3) has been used for purification of water due to its efficiency and lack of side effects. Objectives: The aim of this study was ...
IADR Abstracts; 0714 Low concentration ozone treatment insufficient to control DUWL biofilm B.E. CARDON 1, P.D. ELEAZER 2, R.D. MILLER 1, and R.H. STAAT 1, 1 University of Louisville, KY, USA, 2 University of Alabama at Birmingham, USA. Most general practice dental unit water lines (DUWL) harbour biofilms that continually ...
IADR Abstracts; 2183 Primary Colonization of DUWL by P. aeruginosa and its Eradication by Ozone H. AL SHORMAN, L. ABU-NABA'A, W.A. COULTER, and E. LYNCH, Queen's University Belfast, United Kingdom. Pseudomonas aeruginosa (P.A.) may colonise Dental Unit Waterlines (DUWL) and be a risk for immunocompromised adults and ...
IADR Abstracts; Biofilm Control - Ozonation in an Automated Waterline Cleaning Dental Unit.
... Unit R. PUTTAIAH, S.M. LIN, and R. CEDERBERG,
Baylor College of Dentistry, Dallas, TX, USA. Objectives: To study the effects of water dissolved ozone as a sanitizer in an automated waterline cleaning dental unit to control microbial contamination. Methods: A Logos Jr. Dental Unit equipped with an Autosteril ...

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Financial Implications of Ozone Treatment in Dental Care

Domingo H, Holmes J. Reduction in treatment time with combined air abrasion and ozone compared to traditional ‘Drill & Fill’. IADR abstract 2004.
Domingo H, Holmes J. Reduction in Treatment Time with Combined Air Abrasion and ozone, compared to Traditional Drill and Fill, and cost comparison. IADR Abstract 2004.
Domingo H, Holmes J, Abu-Naba’a L, Al Shorman H, Holmes J, Baysan A, Freeman R. Economic Savings Treating Root Caries with Ozone or Air Abrasion.
Johnson N, Johnson J, Lynch E. Cost Benefit Assessment of a Novel Ozone Delivery System vs. Conventional Treatment. IADR Abstract 2003.
Johnson N, Johnson J, Johnson K, et al. Patients’ attitudes to dental treatment using ozone vs. conventional treatment. J Dent Res 2003; 82:A-679. (Abstr)

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Water Sterilisation

Katzeneleson E. Inactivation of viruses and bacteria by ozone. In chemistry of water supply, treatment and disinfection. Ann Arbor Science Publishers Inc., Ann Arbor, Mich, 1974, pp. 153.
Vaughan JM. Inactivation of human and simian rotaviruses by ozone. Appl Environ Microbiol 1987; 53: 2218-2221

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Bio-Chemistry / Toxicology of Ozone & Ozonoids

Arteaga ME, Molerio J, Bada A, González B, Zamora Z, Remigio AC. Clasificación toxicológica del OLEOZON®", Revista CENIC Ciencias Biológicas, 32(1):57-59 (2001).
Arteaga ME, Moleiro J, Zamora Z, Bada AM, González B, Remigio AC. Evaluación del Oleozon® en ensayo de Toxicidad de Clases. OZ-P-130.
Díaz M, Gavin J, Hernández F, Ledea O, Moleiro J. "1H NMR Study of methyl linoleate Ozonation", Ozone Sci. & Eng., 2002.
Díaz M, Hernández F, Alvarez I, Vélez H, Ledea O, Molerio J. "1H-NMR studies of the ozonation of methyl oleate", Boletín de la Sociedad Chilena de Química, 42(3):349-353 (1997).
Díaz M, Hernández F, Alvarez I, Velez H, Ledea O, Moleiro J. "La espectroscopía de resonancia magnética nuclear protónica en el seguimiento de la reacción del ozono con los ácidos grasos insaturados", Revista CENIC Ciencias Químicas, 29:89 93 (1998).
Díaz M, Lezcano I, Molerio J and Hernández F. "Spectroscopic characterization of ozonides with biological activity", Ozone Sci. & Eng., 23(1):35-40 (2001).
Fernández S, Quinsan C, Menéndez S, Gómez M. "Evaluación mutagénica del aceite ozonizado administrado intragástricamente", Revista CENIC Ciencias Biológicas, 20(1-2-3):14-16 (1989).
Fernández SI, Quinzan C, Menéndez S, Gómez M. "Estudio en animales de experimentación de posibles efectos teratogénicos y mutagénicos por vía intraperitoneal e intramuscular", Revista CENIC Ciencias Biológicas, 20(1-2-3):45-47 (1989).
Gell A, Pérez O, Lastre M. "Ozonoterapia en gerbils infectados experimentalmente con Giardia lamblia", Revista CENIC Ciencias Biológicas, 20(1-2-3):55-58 (1989).
Hernandez F, Moleiro J, Fernandez I, Regüeiferos MG. "Estudio in vitro del Lipofundin S-20 ozonizado", Revista CENIC Ciencias Biológicas, 20(1-2-3):5-8 (1989).
Jardines D, Ledea O, Zamora Z. Dicarboxylic Acids and their Origins in the Oral Administration of Oleozon®. OZ-P-128.
Jardines D, Ledea O, Zamora Z. "Triglicéridos insaturados ozonizados como precursores de ácidos dicarboxílicos urinarios de ratas Wistar", Revista CENIC Ciencias Químicas, 32(2):65-69 (2001).
Jardines D, Zamora Z, Correa T, Rosado A, Moleiro J. "Perfil de ácidos orgánicos urinarios en ratas tratadas con oleozon por vía oral", Revista CENIC Ciencias Químicas, 29(2):79-84 (1998).
Ledea O, Correa T, Molerio J, Jardines D, Escobar M, Rosado A. "Volatile Components of Ozonized Sunflower Oil (OLEOZON®), Ozone Sci. & Eng., 23(2):121-126 (2001).
Ledea O, Escobar M, Rosado A, Correa T, Jardines D, Molerio J. "Determinación de los compuestos polares presentes en el OLEOZON", Revista CENIC Ciencias Químicas, 31(3):195-202 (2000).
Ledea O, Jardines D, Moleiro J et al. "Nuevo método para el análisis de ozónidos del oleato de metilo por CG-EM", Revista CENIC Ciencias Químicas, 28:139-140 (1997).
Ledea O, Moleiro J, Díaz M, Jardines D. "Análisis de ozónidos y compuestos peroxídicos en la ozonización de oleato de metilo", Revista CENIC Ciencias Químicas, 29(2):75-78 (1998).
Lynch E, Grootveld M, Holmes J, Silwood C, Claxson AWD, Prinz J, Toms H. 1H NMR Analysis of Ozone-treated Grapeseed, Olive, and Sunflower Seed Oils. AADR Abstract 182; 2003.
Menéndez S, Falcón L. "Ozonized sunflower oil in the treatment of tinea pedis", Mycoses, 44 (2001).
Menéndez S, Moleiro J, Díaz W, Lezcano I, León FL, Ledea O, Falcón L, Simón RD, Pérez O, Moya S, Landa N, Hernández C, Fernández LA, Díaz M, Gómez M, Jardines D, Aquino A, Mora C, Pérez C. Registro Sanitario sobre la Application del Aceite de Girasol Ozonizado Oleozon® en la Epidermofitosis®". OZ-P-132.
Noa M, Hernández F, Herrera M, Menéndez S, Capote A, Aguilar C. "Estudio histológico de vías digestivas de ratones tratados con aceite ozonizado", Revista CENIC Ciencias Biológicas, 20(1-2-3):23-24 (1989).

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General Medicine

Cas as M, Conde B, Ramos F. Our Experiences in the use of Ozone Therapy in the Elderly.
Falcón L, Simón D, Menéndez S, Moya S, Garbayo E, Díaz W. Experiences of Nine Years Using Ozonated Oil in Dermatology.
Gutiérrez M, Lezcano I, Sánchez E, Baluja C. Ozone Inactivation Kinetic of Antibiotic Multi-resistant Strains of Bacteria. OZ-P-061.
Jiménez I, Aguiler G, Moro R, Torrez EL, Domínguez P. The use of Ozone in Medicine. Caustical Analysis.

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Treatment of Infections - Bacterial

Chang H, Fulton C, Lynch E. Antimicrobial Efficacy of Ozone on Enterococcus faecalis. IADR Abstract 2003
Contreras OR, Gómez M, Menéndez S, Molerio J, Roura G, Fernández D, Eng L. "Efecto de la sustitución del aceite de oliva por aceite de girasol en la actividad antimicrobiana del aceite ozonizado", Revista CENIC Ciencias Químicas, 20(1-2-3):121-124 (1989).
González M, Molerio J. "Evaluación de la acción fungicida del ozono frente a Aspergillus flavus y a productos vegetales contaminados con este hongo", Revista CENIC Ciencias Químicas, 20(1-2-3):118-121 (1989).
Katzeneleson E. Inactivation of viruses and bacteria by ozone. In chemistry of water supply, treatment and disinfection. Ann Arbor Science Publishers Inc., Ann Arbor, Mich, 1974, pp. 153.
Lezcano I, Nuñez N, Gutiérrez M, Molerio J. "Actividad in vitro de aceite de girasol ozonizado frente a diferentes especies bacterianas", Revista CENIC Ciencias Biológicas, 27(1-2-3):46-49 (1996).
Lezcano I, Núñez N, Espino M, Gómez M. "Antibacterial activity of ozonized sunflower oil, Oleozon, against Staphylococcus aureus and Staphylococcus epidermis", Ozone Sci. & Eng., 22(2):207-214(2000).
Holmes J. Management of Volatile Sulphur Compounds with Ozone. ISBOR 2003
Holmes J. The use of Ozonated Water as a Mouth Rinse to Reduce Bad Breath. IADR, 2003
Ishizaki K. Inactivation of bacillus spores by gaseous ozone. J Applied Bacteriol 1986; 60: 67-72.
Nagayoshi M, Fukuizumi T, Kitamura C, et al. Efficacy of ozone on survival and permeability of oral microorganisms. Oral Microbiol Immunol 2004; 19:240–246.
Sechi LA, Lezcano I, Nuñez N, Espino M, Dupre I, Pinna A, Molicotti P, Fadda G, Zanetti S. "Antibacterial activity of ozonized sunflower oil (Oleozon)", J Appl. Microbiology, 90(2):279-284 (2001).
Yamayoshi T, Tatsumi N. Microbicidal effects of ozone solution on methicillinresistant Staphylococcus aureus. Drugs Exp Clin Res 1993; 19:59–64.

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Treatment of Infections - Fungal

Bolgov V. Ozone Therapy in Obliterating Arterial Diseases of Lower Extremities.
González M, Molerio J. "Evaluación de la acción fungicida del ozono frente a Aspergillus flavus y a productos vegetales contaminados con este hongo", Revista CENIC Ciencias Químicas, 20(1-2-3):118-121 (1989).
Shargawi JM, Theaker ED, Drucker DB, et al. Sensitivity of Candida albicans to negative air ion streams. J Appl Microbiol 1999; 87:889–897.

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Treatment of Infections - Viral

Delgado J, Wong W, Regalado1 CP, Noriega A. Subcutaneous Ozone Therapy in the Treatment of Herpes Simplex.
Katzeneleson E. Inactivation of viruses and bacteria by ozone. In chemistry of water supply, treatment and disinfection. Ann Arbor Science Publishers Inc., Ann Arbor, Mich, 1974, pp. 153.
Vaughan JM. Inactivation of human and simian rotaviruses by ozone. Appl Environ Microbiol 1987; 53: 2218-2221

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Treating Skin Infections and Diseases

Alyochina S, Chrychyva T, Ovchynicov V, Kontorshchikova C. Ozone in the Treatment of Peripheral Circulation Disorders in Lower Extremities.
Calderon NA, Kaufman T. The Microclimate Chamber: Topical Treatment of Long-Enduring Leg Ulcers with Ozone. OZ-PO-056.
Falcón L, Simón D, Menéndez S, Moya S, Garbayo E, Díaz W. Experiences of Nine Years Using Ozonated Oil in Dermatology.
Gorbunov S, Gorbunova L, Romashov PH, Dmitriev V, Isaev V. Total Ozone Therapy of Trophic Ulcers of Lower Extremities in Elderly Patients.
Gutiérrez M, Lezcano I, Sánchez E, Baluja C. Ozone Inactivation Kinetic of Antibiotic Multi-resistant Strains of Bacteria. OZ-P-061.
Holmes J. Ozonoids and Omega 3, 6 and 9 Fatty Acids in Skin Care; an Innovative Perspective. Awaiting Publication, February 2006.
Holmes J. Application of Modern Chemistry to Historical Uses of Vegetable and Plant Extracts. Awaiting Publication, February 2006.
Holmes J. New Research into Skin Care. Awaiting Publication, January 2007.
Holmes J. Ozone, Ozonoids and Omega 3, 6 and 9 Fatty Acids in Skin Care; an Innovative Perspective. Awaiting Publication, April 2007.
Holmes J. Honey - Rediscovering Natural Additives for Skin Treatment. Awaiting Publication, April 2007.
Pavlovskaya E, Sultanova I, Maslennikov O. Effectiveness of Ozone Therapy in the Process of Diabetes Treatment.
Potekhina Y, Gustov A, Peretyagin S, Dmitriev G, Karpovich E. The Use of Ozone Therapy in Diseases of Peripheral Nervous System.

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Treating Ear Infections with Ozone

Durañona RA, Menéndez S, Rivero OE, Nieves A. Ozone Therapy in Suppurative Chronic Middle Ear Disease.
Shakhov V, Edeleva A. The Use of Ozone Therapy in Chronic Purulent Mesotympanitis.

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Infections of the Throat.

Holmes J. Management of Volatile Sulphur Compounds with Ozone. ISBOR 2003
Holmes J. The use of Ozonated Water as a Mouth Rinse to Reduce Bad Breath. IADR, 2003
Silva L, Wong R. Ozone Therapy in Chronic Tonsillitis.

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Internal Use of Ozonoids - Upper Gut

Hernández D, Hernández F, Zamora Z, González M, Ancheta O, Torres D, Bouza M. In-Vitro and In-Vivo Effects of Oral Oleozon® on Giardia Lamblia Trophozoites. OZ-PO-060.
González MF, Menéndez S, Cedeño N, Orvera G, Díaz W. Ozonized Oil (Oleozon) in the Treatment of Children Suffering Of Giardiasis.
González ME, Menéndez S, Escobedo A, Hernández J, Piñol F, Cedeño N, Díaz W. Therapy Effects of Ozonized Oil (Oleozon) in the Treatment of Giardiasis.

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Internal Use of Ozonoids - Lower Gut

Bustelo J, Vega G. Clinical Comparative study of Ozone Therapy and Metronidazole in Intestinal Amebiasis.
Casas M, Conde B, Ornia M, Ramos F. Ozone Therapy in Demential Syndrome in the Elderly.
Chang H, Fulton C, Lynch E. Antimicrobial Efficacy of Ozone on Enterococcus faecalis. IADR Abstract 2003
Llibre JJ, Samper JA, Laucerique T, Pérez Z. Treatment of Senile Dementia of Alzheimer Type with Ozone Therapy and Electromagnetic Field.
Morris G, Menéndez S. Application of Oleozon in the Haemorrhoids.
Puga R, Rodríguez R, González C, Muñoz J. Ozone Therapy in the Treatment of Patients with Secondary Immunodeficiencies.
Rodríguez MM, García J, Menéndez S, Devesa E, Cámbara A. Ozone Therapy in the Treatment of Elderly Patients Suffering from Parkinson’s Syndromes.
Rodríguez MM, García J, Menéndez S, Devesa E, González R. Ozone Medical Application in the Treatment of Senile Dementia.
Rodríguez MM, García J, Menéndez S, Devesa E, Valverde S. Application of ozone Therapy in Ischemic Cerebrovascular Disease.

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Internal Use of Ozonoids - Vaginal

Ananiev VA, Zuev VM. Ozonetherapy in a Case of Obstetric Traumatism. OZ-P-090:
Kachalina TS, Gretchkanev GO, Kachalina OV, Mazepa VN, Katkova N, Soshnikov AV, Povechtchenko OA. Ozone Therapy in Bacterial Vaginosies and Colpitis. OZ-P-100:
Morris G, Menéndez S. Oleozon in Gynaecology.

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Treatment of Infections - Bone Infections

Escarpanter JC. Ozone Therapy in the Treatment of Bone Infections.

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Internal Use of Ozone & Ozonoids – Lung Disease

Belyanin II. Effect of Blood Ozonization on the course of Progressive Tuberculosis of the Lungs Associated with Diabetes Mellitus. Terapevticeskij arhiv 69:1111, 44-48, Medicina, 1997.
Holmes J. The Use of Ozone (O3) to Treat Tuberculosis. Literature Review. Awaiting Publication July 2007.

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Internal Use of Ozone & Ozonoids - Cancer

Borrego L, Borrero LL, Díaz EC, Menéndez S, Borrego LR, Borrego RA. Ozone Plus Cobalt Therapy in Patients Suffering from Prostatic Cancer.
Clavo B, Lloret M, López L, Suárez G, Santana M, Pérez JL, Rodríguez V, Macías D, Hernández MA, Martín-Oliva R, Rovira G, Günderoth M. Tumour pO2 Modification by Ozonetherapy. OZ-PO-039.

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Topical Use of Ozone & Ozonoids - Cancer

Rovira G, López L, Suárez G, Santana M, Clavo B, Pérez JL, Lloret M, Rodríguez V, Macías D, Hernández MA, Martín R, Robaina F. Local Ozonetherapy for Delayed Scaring in Cancer Patients. OZ-PO-046.


2015
© Dr Julian Holmes